Manx syndrome is a genetic condition that affects the development of the spine and limbs in cats. It is caused by a mutation in the T-box gene, which is responsible for the formation of the vertebrae and limbs. Manx syndrome can range in severity from mild to severe, and it can affect both male and female cats.

The most common symptom of Manx syndrome is a shortened or absent tail. In severe cases, the spine may be deformed, and the cat may have difficulty walking or using its hind legs. Other symptoms of Manx syndrome can include: